These nanoparticles are readily synthesized in different sizes to yield efficient and tunable short-wavelength light emission under near-infrared excitation, which eliminates optical background interference of the specimen. We have overcome the shortcomings of currently available staining and fluorescence labeling methods by taking an integrative approach to establish photon-upconversion nanoparticles (UCNP) as a powerful platform for cancer detection. Current methods are limited in terms of sensitivity, hindering early detection of disease. ![]() ![]() The detection of cancer biomarkers in histological samples and blood is of paramount importance for clinical diagnosis.
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